DMCA. Copyrighted Work that you can Claim.
Base have 45 000 books.
Search: 


๐Ÿ“™ The Role of Genetics in Breast and Reproductive Cancers by Robin L. Bennett (auth.), Piri Welcsh (eds.) โ€” free epub


Of all factors contributing to breast cancer, family history of disease is the most powerful. Currently, our understanding of genetic predisposition to breast cancer includes three classes of genes as defined by their associated risks. BRCA1 and BRCA2 are high-penetrance breast cancer predisposition genes. Since the cloning of BRCA1 and BRCA2, inherited mutations in an additional 8 genes, all of which are functionally related to BRCA1 and/or BRCA2, have been shown to variously confer a low-intermediate increased breast cancer risk. Furthermore, recent genome-wide association studies have uncovered eight common variants associated with low-penetrance breast cancer predisposition. Despite these discoveries, most of the familial risk of breast cancer remains unexplained.

The Role of Genetics in Breast and Reproductive Cancers is divided into three parts: Recognition of Hereditary Breast and Reproductive Cancer Syndromes, Genetic etiology of breast and reproductive cancers, and Genes and the environment. In the first section, we discuss how genetic counselors and clinicians acknowledge hereditary breast and reproductive cancer syndromes, with an emphasis on the challenges and responsibilities of counseling women in understanding the role of family history in dictating personal cancer risk. This section includes a detailed discussion of the current recommendations for clinical management of women with inherited mutations in BRCA1 and BRCA2.

Section II focuses on the impact of inherited mutations in known breast cancer genes on the etiology of breast and reproductive cancers, and the challenges of determining cancer risk when genetic testing reveals variants of unknown consequence in BRCA1 and BRCA2. Because the cellular function of BRCA2 has so elegantly been revealed, we devote a chapter to the current understanding of BRCA2 function and how loss of function contributes to disease development. In addition, we present a discussion of genetic modifiers of risk of BRCA1- and BRCA2-related cancers, and chapters on other hereditary breast cancer syndromes and genes, and ovarian and endometrial cancers in patients with Hereditary Non-Polyposis Colorectal Cancer syndrome. Finally, we conclude this section with two chapters that respectively discuss somatic alterations in breast and in ovarian cancer.

The third and final section discusses how recent advances in genomic technologies are being applied to decipher the intricate relationship between genetic variation and the environment, to better predict individual cancer risk, and to development of reagents for disease prevention and treatment. We conclude with a discussion of the role of epigenetics in breast and ovarian cancer development. This final chapter focuses on the exciting prospect that epigenetic changes can be used as predictive and prognostic biomarkers and, because they are reversible, targets for development of pharmacologic reagents to manage disease.

Piri L. Welcsh, PhD is a Research Assistant Professor in the Department of Medicine, Division of Medical Genetics at the University of Washington. She received her PhD in Molecular Genetics from The Ohio State University. It was during this time that the seminal paper in which Dr. Mary-Claire King demonstrated that a single gene on chromosome 17, later known as BRCA1, was responsible for many breast and ovarian cancers was published. During Postdoctoral studies at the University of Texas Southwestern Medical Center in Dallas, Dr. Welcsh worked under the guidance of Dr. Anne M. Bowcock and collaborated with Drs. Mary-Claire King and Francis Collins in an attempt to clone BRCA1. Shortly after the gene encoding BRCA1 was identified, Dr. Welcsh joined the research group of Dr. King at the University of Washington where she conducted studies designed to elucidate the biological function of BRCA1. She is currently an independent investigator whose current research goals include the identification and characterization of both genetic and epigenetic mechanisms critical to the development of breast and ovarian cancer.



About book:

About file:

  • File size: 4 889 196
  • Format: pdf


Security code:
Download button

Similar books results


Genetic Susceptibility to Cancer
Genetic Susceptibility to Cancer free download by Seymour Garte (auth.)

Despite recent progress in many areas of treatment and control, cancer remains a frightening threat to everyone. While scientists have known for decades that the majority of human cancers are caused by environmental agents such as radiation and the chemic...

Genetics of Colorectal Cancer
Genetics of Colorectal Cancer free epub by John D. Potter MD, PhD, David Hunter (auth.), John D. Potter MD, PhD, Noralane M. Lindor MD (eds.)

The last 20 years have seen a remarkable increase in knowledge of the etiology of colorectal cancer. At least three aspects are much clearer. First, known environmental agents and behaviors have been identified that increase risk (for example, diets high ...

Cancer in the elderly
Cancer in the elderly download pdf by Carrie P. Hunter, Karen Audrey Johnson, Hyman B. Muss

This book presents comprehensive assessment and up-to-date discussion of the epidemiology, prevention, and treatment of cancer in the elderly, highlighting the growing demands of the disease, its biology, individual susceptibility, the impact of state-of-...

Challenges in Prostate Cancer, Second Edition
Challenges in Prostate Cancer, Second Edition free epub by

Prostate cancer continues to be a major threat to men's health, the second most common cancer in men, in many countries. Therefore it is increasingly important that those faced with difficult clinical questions make the right decisions. Since the first vo...

The Biology of Gastric Cancers
The Biology of Gastric Cancers epub download by Pelayo Correa, M. Constanza Camargo, M. Blanca Piazuelo (auth.), Timothy C. Wang, James G. Fox, Andrew S. Giraud (eds.)

There have been many impressive advances in our understanding of the pathogenesis of gastric adenocarcinoma, gastric MALT lymphoma, gastrointestinal stromal tumors of the stomach, and gastric carcinoid tumors over the years. "The Biology of Gastric Cancer...

Multidisciplinary Management of Prostate Cancer: The Role of the Prostate Cancer Unit
Multidisciplinary Management of Prostate Cancer: The Role of the Prostate Cancer Unit free epub by Vincenzo Gentile, Valeria Panebianco, Alessandro Sciarra (eds.)

Prostate cancer is the most common neoplasm in men and its management is very complex, in terms of both diagnosis and treatment. In recent years the value of multidisciplinary management within a prostate cancer unit has been increasingly recognized. Such...

Checkpoint Controls and Cancer: Volume 1: Reviews and Model Systems
Checkpoint Controls and Cancer: Volume 1: Reviews and Model Systems epub download by Hiroshi Nojima (auth.), Axel H. Schรถnthal PhD (eds.)

Intracellular checkpoint controls constitute a network of signal transduction pathways that protect cells from external stresses and internal errors by means of cell cycle arrest, DNA repair, or apoptosis. Failure of this machinery can lead to embryonic d...

The Autoimmune Diseases I
The Autoimmune Diseases I pdf free by Ian R. Mackay and Noel Richard Rose (Auth.)

This edition discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels. In addition to a comprehensive discussion of various autoimmune diseases and organ systems, the editors also cover the role of autoimmunity i...

Rare Hereditary Cancers: Diagnosis and Management
Rare Hereditary Cancers: Diagnosis and Management download pdf by Gabriella Pichert, Chris Jacobs (eds.)

This book approaches the differential diagnosis and management of rare, hereditary cancer syndromes from a practical angle, addressing the issues pertinent to each tumour type as encountered by health professionals in their day-to-day practice. This book ...

  Jdbc Api Tutorial And Reference 3rd Ed
Jdbc Api Tutorial And Reference 3rd Ed free pdf by Maydene Fisher, Jon Ellis, Jonathan Bruce

This book provides the definitive tutorial and reference to the JDBC API, the technology that enables universal data access for the Java programming language. This new edition has been updated and expanded to cover the entire JDBC 3.0 API, including the j...

JD Edwards EnterpriseOne, The Complete Reference
JD Edwards EnterpriseOne, The Complete Reference download pdf by Allen Jacot, Joseph Miller, Michael Jacot, John Stern

Your definitive guide to JD Edwards EnterpriseOneImplement and maintain a fully integrated, SOA-based ERP framework across your entire corporation. JD Edwards EnterpriseOne: The Complete Reference explains how to install and administer JD Edwards Enterpri...

jBPM Developer Guide

Java(TM) Development on PDAs: Building Applications for Pocket PC and Palm Devices
Java(TM) Development on PDAs: Building Applications for Pocket PC and Palm Devices download pdf by Daryl Wilding-McBride

I bought it for a friend and never heard a complain about it. I guess it's a good book....

Jdbc Database Access With Java: A Tutorial and Annotated Reference
Jdbc Database Access With Java: A Tutorial and Annotated Reference free download by Graham Hamilton, Rick Cattell, Maydene Fisher

Provides explanations of JDBC and Java fundamentals, a step-by-step tutorial to bring you up tp speed, and an extensively annotated reference to all JDBC classes and interfaces. Paper. ...

  Javelinas and Other Peccaries: Their Biology, Management, and Use (W L Moody, Jr, Natural History Series)

JavaScript: The Missing Manual
JavaScript: The Missing Manual pdf free by David Sawyer McFarland

JavaScript is an essential language for creating modern, interactive websites, but its complex rules challenge even the most experienced web designers. With JavaScript: The Missing Manual, you'll quickly learn how to use JavaScript in sophisticated ways -...

Jazz Books in the 1990s: An Annotated Bibliography
Jazz Books in the 1990s: An Annotated Bibliography pdf free by Janice Leslie Hochstat Greenberg

Jazz Books in the 1990s: An Annotated Bibliography contains over 700 entries covering adult non-fiction books on jazz published from 1990 through 1999. International in scope, the books included range from such places as Finland, Slovakia, Australia, Japa...

JBoss AS 7 Development: Develop, deploy, and secure Java applications on the new release of this robust, open source application server
JBoss AS 7 Development: Develop, deploy, and secure Java applications on the new release of this robust, open source application server free epub by Francesco Marchioni

JBoss Application Server meets high standards of reliability, efficiency, and robustness, and is used to build powerful and secure Java EE applications. It supports the most important areas of Java Enterprise programming including EJB 3.1, Contexts and De...

JavaServer Faces in Action
JavaServer Faces in Action free epub by Kito D. Mann

JavaServer Faces helps streamline your web development through the use of UI components and events (instead of HTTP requests and responses). JSF components (buttons, text boxes, checkboxes, data grids, etc.) live between user requests, which eliminates th...