DMCA. Copyrighted Work that you can Claim.
Base have 45 000 books.
Search: 


📙 Drug Discovery: A Casebook and Analysis by Robert A. Maxwell, Shohreh B. Eckhardt (auth.) — download pdf


This treatise had its origins in the authors' strong opinion that the discovery of new drugs, especially of innovative therapeutic agents, really does not happen as a spontaneous sequel to investiga­ tive research, no matter how penetrating such research may be. Rather, it seemed to us that the discovery of innovative therapeutic agents was a very active process, existing in and of itself, and demanding full attention-it was not simply a passive, dependent by-process of investigative research. And yet, many researchers­ some close confreres of the authors, others more distant-believed otherwise. We felt that their view reflected unrealistic thinking and that reality probably lay closer to what Beyer" maintained: We are taught to believe that if we can understand a disease it should be easy enough to figure out, say, the molecular configuration of a definitive receptor mechanism somewhere along the line and to design a specific drug . . . . And so we start out to understand the disease but never get around to doing much about therapy. The authors very soon realized that there was essentially no quantitive information available on just where and how innovative therapeutic agents were discovered. There were only anecdotal accounts, and these were able to be selected and presented in ways that could be used to defend any point of view.



About book:

About file:

  • File size: 13 883 927
  • Format: pdf


Security code:
Download button

Similar books results


Flow Cytometry in Drug Discovery and Development
Flow Cytometry in Drug Discovery and Development free epub by

This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The ...

PharmacoKinetics in Drug Discovery and Development
PharmacoKinetics in Drug Discovery and Development free download by Ronald D. Schoenwald

Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a fu...

Real World Drug Discovery: A Chemist's Guide to Biotech and Pharmaceutical Research
Real World Drug Discovery: A Chemist's Guide to Biotech and Pharmaceutical Research free pdf by Robert M. Rydzewski

Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not ha...

DRUG DISCOVERY STRATEGIES AND METHODS
DRUG DISCOVERY STRATEGIES AND METHODS free pdf by Alexandros Makriyannis, Diane Biegel

Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimizat...

Integrated Drug Discovery Technologies
Integrated Drug Discovery Technologies free download by Houng-Yau Mei, Anthony W. Czarnik

Rubicon Genomics, Inc., Ann Arbor, MI. Reference provides a global overview of emerging drug discovery technologies. Presents new techniques from the disciplines of chemistry, biology, and computational sciences. Explains the rationale and developmental b...

Drug Discovery Strategies and Methods
Drug Discovery Strategies and Methods free download by Alexandros Makriyannis

Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimizat...

Systems Biology in Drug Discovery and Development: Methods and Protocols
Systems Biology in Drug Discovery and Development: Methods and Protocols free epub by Bulbul Chakravarti, Buddhadeb Mallik, Deb N. Chakravarti (auth.), Qing Yan (eds.)

Due to the failing “one-drug-fits-all” model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. In Systems Biology in Drug Discovery and D...

Structure-Based Drug Discovery
Structure-Based Drug Discovery free pdf by Harren Jhoti, Andrew R. Leach (auth.)

Discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major i...

Mouse Models for Drug Discovery: Methods and Protocols
Mouse Models for Drug Discovery: Methods and Protocols free download by Michael F.W. Festing (auth.), Gabriele Proetzel, Michael V. Wiles (eds.)

As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has...

TRP Channels in Drug Discovery: Volume I
TRP Channels in Drug Discovery: Volume I free epub by Bernd Nilius (auth.), Arpad Szallasi, Tamás Bíró (eds.)

Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels ha...

FDA and Worldwide Quality System Requirements Guidebook for Medical Devices
FDA and Worldwide Quality System Requirements Guidebook for Medical Devices download pdf by Daniel, Amiram; Kimmelman, Ed

This new and expanded Second Edition maintains the organizational approach of the first and includes the requirements and guidance contained in the Quality System Regulation (QSReg), the ISO 13485:2003 standard, the ISO/TR 14969:2004 guidance document, an...

Multivariate Analysis–III. Proceedings of the Third International Symposium on Multivariate Analysis Held at Wright State University, Dayton, Ohio, June 19–24, 1972

Justice and Responsibility—Sensitive Egalitarianism

Easily into WordPerfect 5®
Easily into WordPerfect 5® free pdf by Joanna Gosling (auth.)

Israel the Peaceful Belligerent, 1967–79
Israel the Peaceful Belligerent, 1967–79 free epub by Amnon Sella, Yael Yishai (auth.)

An Economic and Social History of Europe, 1890–1939
An Economic and Social History of Europe, 1890–1939 free pdf by Frank B. Tipton, Robert Aldrich (auth.)

Lean Enterprise Value: Insights from MIT’s Lean Aerospace Initiative
Lean Enterprise Value: Insights from MIT’s Lean Aerospace Initiative free pdf by Earll Murman, Thomas Allen, Kirkor Bozdogan, Joel Cutcher-Gershenfeld, Hugh McManus, Deborah Nightingale, Eric Rebentisch, Tom Shields, Fred Stahl, Myles Walton, Joyce Warmkessel, Stanley Weiss, Sheila Widnall (auth.)

Communal Labor in Colonial Kenya: The Legitimization of Coercion, 1912–1930

‘Abdu’l-Bahá’s Journey West: The Course of Human Solidarity

The Beginnings of University English: Extramural Study, 1885–1910